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Article

Human ageing impairs injury-inducedin vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA

1 Oct 1997

Abstract excerpt

Proteolysis is an essential component of wound healing but, if uncontrolled, it may lead to degradation of the neo-matrix and a delay in wound repair. Despite numerous reports of impaired wound healing associated with increasing age, the control of proteolysis is completely unknown. Tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 inhibit the activity of matrix metalloproteinases and the pattern of...

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PMID: 9390029
DOI: 10.1002/(sici)1096-9896(199710)183:2<169::aid-path915>3.0.co;2-q

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