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Article

Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis

1 Feb 2003

Abstract excerpt

Reactive oxygen and nitrogen are produced by rheumatoid arthritis (RA) synovial tissue and can potentially induce mutations in key genes. Normally, this process is prevented by a DNA mismatch repair (MMR) system that maintains sequence fidelity during DNA replication. Key members of the MMR system include MutSalpha (hMSH2 and hMSH6) and MutSbeta (hMSH2 and hMSH3). To provide evidence of DNA damage in inflamed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12574395
DOI: 10.4049/jimmunol.170.4.2214

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