Article
Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 1997
Firestein G S, Echeverri F, Yeo M, Zvaifler N J, Green D R
Abstract excerpt
The factors that regulate the perpetuation and invasiveness of rheumatoid synovitis have been the subject of considerable inquiry, and the possibility that nonimmunologic defects can contribute to the disease has not been rigorously addressed. Using a mismatch detection system, we report that synovial tissue from the joints of severe chronic rheumatoid arthritis patients contain mutant p53 transcripts, which were...
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