Article
Regional analysis of p53 mutations in rheumatoid arthritis synovium.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2002
Yamanishi Yuji, Boyle David L, Rosengren Sanna, Green Douglas R, Zvaifler Nathan J, Firestein Gary S
Abstract excerpt
The p53 tumor suppressor protein plays a central role in cell cycle regulation, DNA repair, and apoptosis. Recent studies indicate that DNA damage and somatic mutations in the p53 gene can occur because of genotoxic stress in many tissues, including the skin, colon, and synovium. Although somatic mutations in the p53 gene have been demonstrated in rheumatoid arthritis (RA) synovial tissue and synoviocytes, no...
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