Article
Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue.
Clinical and experimental immunology - 1 Feb 1998
Rème T, Travaglio A, Gueydon E, Adla L, Jorgensen C, Sany J
Abstract excerpt
Erosive rheumatoid arthritis (RA) is accompanied by synovial tissue hyperplasia associated with the proliferation of transformed-appearing synovial lining cells. In the present study we have analysed the expression of the p53 tumour suppressor gene in the synovial pannus tissue from patients at various stages of the disease. We used a combination of polymerase chain reaction (PCR) and single-strand conformation...
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