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Article

Fewer nephrons at birth: a missing link in the etiology of essential hypertension?

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jul 1995

Mackenzie H S, Brenner B M

Abstract excerpt

In 1988, Brenner et al advanced the hypothesis that the nephron endowment at birth is inversely related to the risk of developing essential hypertension in later life (Am J Hypertens 1:335-347, 1988). This novel perspective on the origins of essential hypertension was taken from the viewpoint that the development and maintenance of hypertension must involve a renal factor favoring sodium retention, thereby...

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Identifiers

PMID: 7611275
DOI: 10.1016/0272-6386(95)90161-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fewer nephrons at birth: a missing link in the etiology of essential hypertension?PMID 7611275Read ↗

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Nephron number and its determinants in early life: a primerSemantic proximity Read ↗

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Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKDSemantic proximity Read ↗

Understanding the Role of Maternal Diet on Kidney Development; an Opportunity to Improve Cardiovascular and Renal Health for Future GenerationsSemantic proximity Read ↗

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