Fewer nephrons at birth: a missing link in the etiology of essential hypertension?

doi:10.1016/0272-6386(95)90161-2

Back to search

Article

Fewer nephrons at birth: a missing link in the etiology of essential hypertension?

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jul 1995

Mackenzie H S, Brenner B M

Abstract excerpt

In 1988, Brenner et al advanced the hypothesis that the nephron endowment at birth is inversely related to the risk of developing essential hypertension in later life (Am J Hypertens 1:335-347, 1988). This novel perspective on the origins of essential hypertension was taken from the viewpoint tha...

Topics

Animals
Blood Pressure
Dietary Proteins
Female
Fetal Growth Retardation
Genotype
Humans
Hypertension
Infant, Low Birth Weight
Infant, Newborn
Nephrons
Phenotype
Pregnancy
Rats
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.