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Article

X chromosome inactivation and X-linked mental retardation.

American journal of medical genetics - 12 Jul 1996

Willard H F

Abstract excerpt

The expression of X-linked genes in females heterozygous for X-linked defects can be modulated by epigenetic control mechanisms that constitute the X chromosome inactivation pathway. At least four different effects have been found to influence, in females, the phenotypic expression of genes responsible for X-linked mental retardation (XLMR). First, non-random X inactivation, due either to stochastic or genetic...

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PMID: 8826443
DOI: 10.1002/(SICI)1096-8628(19960712)64:1<21::AID-AJMG2>3.0.CO;2-U

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Source receipt: pubmed, retrieved 7 Sept 2026.

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