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Article

Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.

The Journal of clinical investigation - 1 Feb 2003

Lesnik Philippe, Haskell Christopher A, Charo Israel F

Abstract excerpt

The hallmark of early atherosclerosis is the accumulation of lipid-laden macrophages in the subendothelial space. Circulating monocytes are the precursors of these "foam cells," and recent evidence suggests that chemokines play important roles in directing monocyte migration from the blood to the vessel wall. Fractalkine (FK) is a structurally unusual chemokine that can act either as a soluble chemotactic factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12569158
DOI: 10.1172/JCI15555
PMCID: PMC151849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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