Article

Sudden Death-Associated <i>KCNH2</i> Variants Have Opposing Effects on hERG1 <sub>NP</sub> Function

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> hERG1 NP is a non-conducting subdomain of the full-length hERG1 channel that is expressed in the nuclei of developing cardiomyocytes. From the nucleus, hERG1 NP modulates gating and expression of the full-length hERG1 channel. hERG1 NP variants are linked with sudden death in the young, but the impact of these variants on hERG1 NP activity has not been studied. To determine the effect of hER...

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Literature Corpus work: a3eca52b-640d-5fbb-9846-7e3b0df77177
DOI: 10.1101/2025.10.23.684168

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