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Article

Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease.

Human immunology - 1 Feb 2003

Stuck Bettina J, Pani Michael A, Besrour Foued, Segni Maria, Krause Maren, Usadel Klaus-H, Badenhoop Klaus

Abstract excerpt

Hashimoto's thyroiditis and Graves' disease represent the two most common autoimmune thyroid disorders. Whereas in Hashimoto's thyroiditis FasL expression causes thyrocytes to undergo apoptosis, additional anti-apoptotic molecules appear to protect these cells in Graves' disease. Mutations of the FasL gene were observed in systemic lupus erythematosus. Given its functional relevance for the pathogenesis of...

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PMID: 12559631
DOI: 10.1016/s0198-8859(02)00775-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease.PMID 12559631Read ↗

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Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease.Semantic proximity Read ↗

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