Article
No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.
Clinical endocrinology - 1 Sept 1998
Heward J M, Allahabadia A, Carr-Smith J, Daykin J, Cockram C S, Gordon C, Barnett A H, Franklyn J A, Gough S C
Abstract excerpt
OBJECTIVE: The cytotoxic T lymphocyte associated-4 (CTLA-4) gene is a candidate for T-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. A previously unreported polymorphism of the promoter region of the human CTLA-4 gene has recently been described in a sample of a normal control population. We investigated the...
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