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Article

Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease.

The Journal of clinical endocrinology and metabolism - 1 Mar 1995

Watson P F, French A, Pickerill A P, McIntosh R S, Weetman A P

Abstract excerpt

Using a combination of polymerase chain reaction amplification, oligonucleotide mismatch hybridization, and direct sequencing, we analyzed the distribution of a recently described TSH receptor gene polymorphism in 88 patients with Graves' disease but no clinically apparent eye disease, 53 patients with Graves' disease and associated ophthalmopathy, 39 patients with autoimmune hypothyroidism, and 156 control...

Topics

Alleles
Base Sequence
Genotype
Graves Disease
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Thyrotropin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7883818
DOI: 10.1210/jcem.80.3.7883818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883818-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease.PMID 7883818Read ↗

TSHR intronic polymorphisms (rs179247 and rs12885526) and their role in the susceptibility of the Brazilian population to Graves' disease and Graves' ophthalmopathy.Semantic proximity Read ↗

T cell receptor beta chain gene polymorphisms in Graves' disease.Semantic proximity Read ↗

No association between a thyrotropin receptor gene polymorphism and Graves' disease in the female population.Semantic proximity Read ↗

Genetic profiling in Graves' disease: further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy.Semantic proximity Read ↗

No mutations in the translated region of exon 1 in the TSH receptor in Graves' thyroid glands.Semantic proximity Read ↗

Analysis of the genetic variability of the 1st (CCC/ACC, P52T) and the 10th exons (bp 1012-1704) of the TSH receptor gene in Graves' disease.Semantic proximity Read ↗

KIR gene content does not contribute to susceptibility to Graves' disease.Semantic proximity Read ↗

Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.Semantic proximity Read ↗

A germline single nucleotide polymorphism at the intracellular domain of the human thyrotropin receptor does not have a major effect on the development of Graves' disease.Semantic proximity Read ↗

Lack of an association between alleles of interleukin-1 alpha and interleukin-1 receptor antagonist genes and Graves' disease in a North American Caucasian population.Semantic proximity Read ↗

[Polymorphism of the 52 triplet gene (nucleotide 253) of the TSH receptor in Basedow-Graves patients and in healthy controls].Semantic proximity Read ↗

Lack of association of Graves' disease with the A2 allele of the interleukin-1 receptor antagonist gene in a white European population.Semantic proximity Read ↗

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