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Mouse models of aneuploidy to understand chromosome disorders

1 Nov 2021

Abstract excerpt

An organism or cell carrying a number of chromosomes that is not a multiple of the haploid count is in a state of aneuploidy. This condition results in significant changes in the level of expression of genes that are gained or lost from the aneuploid chromosome(s) and most cases in humans are not compatible with life. However, a few aneuploidies can lead to live births, typically associated with deleterious...

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PMID: 34719726
DOI: 10.1007/s00335-021-09930-z

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