End-Organ Dysfunction in Cystic Fibrosis: Association with Angiotensin I Converting Enzyme and Cytokine Gene Polymorphisms

Abstract excerpt

The clinical course of patients with cystic fibrosis (CF) with functionally similar mutations in the CF transmembrane conductance regulator gene is variable and must therefore relate to secondary genetic and environmental factors. We examined the hypothesis that polymorphisms of certain inflammatory mediator and regulatory genes affect clinical outcome by influencing the degree of end-organ damage. By studying...

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