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Article

Amyloid: morphology and toxicity.

Clinical chemistry and laboratory medicine - 1 Dec 2002

Olofsson Anders, Ostman Johan, Lundgren Erik

Abstract excerpt

We have expressed transthyretin (TTR) mutants which have significantly destabilised tetramers that aggregate into amyloid fibrils via a series of intermediates. We used atomic force microscopy to follow the morphology of aggregates during fibril formation. Initially, amorphous aggregates are formed that subsequently mature into fibrillar structures. This observation is interpreted as an optimisation of...

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Identifiers

PMID: 12553429
DOI: 10.1515/CCLM.2002.219

Genes

TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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