Article
Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis.
PloS one - 16 Dec 2010
Pokrzywa Malgorzata, Dacklin Ingrid, Vestling Monika, Hultmark Dan, Lundgren Erik, Cantera Rafael
Abstract excerpt
BACKGROUND: A functional link has been established between the severe neurodegenerative disorder Familial amyloidotic polyneuropathy and the enhanced propensity of the plasma protein transthyretin (TTR) to form aggregates in patients with single point mutations in the TTR gene. Previous work has led to the establishment of an experimental model based on transgenic expression of normal or mutant forms of human TTR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.