Article

From Hummingbird to Elephant: Amyloid Formation in Natural Transthyretin Variants

2026-07-15

Abstract excerpt

Transthyretin (TTR) is a secreted protein associated with cardiac and other amyloid diseases via misfolding. We have previously shown that agitation of human TTR solutions at neutral pH results in aggregation and fibril formation. Here we report that agitation-induced aggregation of TTR from species with very different heart rates (Anna’s hummingbird, hbTTR, and African elephant, aeTTR) differs from that of human...

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Literature Corpus work: 1abb77e9-e2b8-5712-b30e-eb9f9b6bb0c7
DOI: 10.64898/2026.07.09.737598

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