Article
Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004
Reixach Natàlia, Deechongkit Songpon, Jiang Xin, Kelly Jeffery W, Buxbaum Joel N
Abstract excerpt
The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction. Recent reports have stressed the importance of oligomeric intermediates as major cytotoxic species in various forms of amyloidogenesis. We have examined the cytotoxic effects of several quaternary structural states of wild-type and...
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