Article
4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2003
Cardoso Isabel, Merlini Giampaolo, Saraiva Maria João
Abstract excerpt
Transthyretin Leu55Pro is one of the most aggressive mutations in familial amyloidotic polyneuropathy, an autosomal dominant disorder characterized by extracellular deposition of fibrillar amyloid protein. This variant has the ability to form fibrils in vitro under physiological conditions (PBS, pH 7.4). We studied by transmission electron microscopy the effect of the drug 4'-iodo-4'-deoxydoxorubicin (I-DOX) on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.