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Article

Glutathione S-transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from southern Italy.

Anticancer research - 1 Jan 2000

Sgambato Alessandro, Campisi Biagina, Zupa Angela, Bochicchio Annamaria, Romano Gianpiero, Tartarone Alfredo, Galasso Rocco, Traficante Antonio, Cittadini Achille

Abstract excerpt

Glutathione S-Transferase (GST) is a phase II enzyme and catalyses reactions between glutathione and a variety of electrophilic compounds, including some environmental carcinogens. In man, at least 20 isoenzymatic forms of GST have been identified and many of them show genetically-based individual variability of enzyme activity. The GSTM1 and GSTT1 isoenzymes display several polymorphisms, including a homozygotic...

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Identifiers

PMID: 12552971

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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