Article
Biomarkers of neuronal injury and amyloid metabolism in the cerebrospinal fluid of patients infected with HIV-1 subtypes B and C.
Journal of neurovirology - 1 Feb 2018
de Almeida Sérgio Monteiro, Ribeiro Clea E, Rotta Indianara, Piovesan Mauro, Tang Bin, Vaida Florin, Raboni Sonia Mara, Letendre Scott, Potter Michael, Batistela Fernandes Meire S, Ellis Ronald J
Abstract excerpt
Based on prior reports that the HIV-1 Tat protein modulates amyloid-beta (Aβ) metabolism, this study aimed to compare CSF neural injury biomarkers between 27 patients with HIV subtype B, 26 patients with HIV subtype C, 18 healthy HIV-negative controls, and 24 patients with Alzheimer's disease (AD). Immunoassays were used to measure soluble amyloid precursor protein α and β (sAPPα, sAPPβ), Aβ oligomers 38, 40, 42,...
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