Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histopathological and cognitive defects induced by Nef in the brain

1 Dec 2004

Abstract excerpt

Complex mechanisms of human immunodeficiency virus type‐1 (HIV‐1) brain pathogenesis suggest the contribution of individual HIV‐1 gene products. Among them, the Nef protein has been reported to harbor a major determinant of pathogenicity in AIDS‐like disease. The goal of the present study was to determine whether Nef protein expressed in vivo by primary macrophages could induce a brain toxicity also affecting the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15576488
DOI: 10.1096/fj.04-2308com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histopathological and cognitive defects induced by Nef in the brainPMID 15576488Read ↗

Modulation in the Gene Expression Profile of Astrocytes and Monocytes by HIV-1 Nef VariantsSemantic proximity Read ↗

The neuropathogenesis of HIV-1 infectionSemantic proximity Read ↗

Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10Semantic proximity Read ↗

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.Semantic proximity Read ↗

Central Nervous System Damage, Monocytes and Macrophages, and Neurological Disorders in AIDSSemantic proximity Read ↗

An Integrated Systems Analysis Implicates EGR1 Downregulation in Simian Immunodeficiency Virus Encephalitis-Induced Neural DysfunctionSemantic proximity Read ↗

Interactions of human immunodeficiency virus‐1 proteins with neurons: possible role in the development of human immunodeficiency virus‐1‐associated dementiaSemantic proximity Read ↗

Monocyte/macrophages and their role in HIV neuropathogenesis.Semantic proximity Read ↗

Novel method to quantify phenotypic markers of HIV-associated neurocognitive disorder in a murine SCID model.Semantic proximity Read ↗

Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment.Semantic proximity Read ↗

The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment.Semantic proximity Read ↗

HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.