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Article

Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated

1 Dec 1996

Abstract excerpt

Two similar, yet functionally distinct genomic RNAs are transcribed from the DNA genome of the human hepatitis B virus. The pre-C RNAs encode the precore protein which is proteolytically processed to yield e antigen. The pregenomic RNAs encode both the nucleocapsid protein and reverse transcriptase and serve as the templates for viral DNA replication. To determine whether synthesis of these two RNAs is directed...

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PMID: 8970999
DOI: 10.1128/jvi.70.12.8719-8726.1996

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Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulatedPMID 8970999Read ↗

Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virusSemantic proximity Read ↗

Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.Semantic proximity Read ↗

Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections.Semantic proximity Read ↗

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replicationSemantic proximity Read ↗

Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA TranscriptionSemantic proximity Read ↗

Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame.Semantic proximity Read ↗

Core promoter: a critical region where the hepatitis B virus makes decisions.Semantic proximity Read ↗

Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamilySemantic proximity Read ↗

The core promoter of hepatitis B virus.Semantic proximity Read ↗

In Vivo Suppression of Precore mRNA Synthesis Is Associated with Mutations in the Hepatitis B Virus Core PromoterSemantic proximity Read ↗

Translation of the first upstream ORF in the hepatitis B virus pregenomic RNA modulates translation at the core and polymerase initiation codonsSemantic proximity Read ↗

Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation.Semantic proximity Read ↗

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