Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of proline to alanine mutation on the thermal stability of the all-beta-sheet protein tendamistat.

Biochimica et biophysica acta - 23 Sept 2003

Zscherp Christian, Aygün Hüseyin, Engels Joachim W, Mäntele Werner

Abstract excerpt

The temperature dependent denaturation of wild-type tendamistat and of the proline-free triple mutant P7A/P9A/P50A was investigated using Fourier-transform infrared (FTIR) spectroscopy. Whereas the temperature-induced unfolding is reversible in the wild type, aggregation was observed for the proline-free tendamistat when studied under the same conditions. The midpoint unfolding temperature T(m) was found as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Enzyme Inhibitors
Share to Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proline

Share to Protein Denaturation

Share to Protein Structure, Secondary

Share to Spectroscopy, Fourier Transform Infrared

Share to Temperature

Source

Identifiers

PMID: 14499598
DOI: 10.1016/s1570-9639(03)00263-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of proline to alanine mutation on the thermal stability of the all-beta-sheet protein tendamistat.PMID 14499598Read ↗

Kinetic mechanism and catalysis of a native-state prolyl isomerization reaction.Semantic proximity Read ↗

Thermodynamic effects of proline introduction on protein stability.Semantic proximity Read ↗

Mechanism of protein stabilization by disulfide bridges: calorimetric unfolding studies on disulfide-deficient mutants of the alpha-amylase inhibitor tendamistat.Semantic proximity Read ↗

Apparent two-state tendamistat folding is a sequential process along a defined route.Semantic proximity Read ↗

Effects of disulfide bonds on folding behavior and mechanism of the beta-sheet protein tendamistat.Semantic proximity Read ↗

Increasing protein conformational stability by optimizing beta-turn sequence.Semantic proximity Read ↗

Influence of proline on the thermostability of the active site and membrane arrangement of transmembrane proteins.Semantic proximity Read ↗

Stability of two beta-tropomyosin isoforms: effects of mutation Arg91Gly.Semantic proximity Read ↗

Biophysical characterisation of the small ankyrin repeat protein myotrophin.Semantic proximity Read ↗

The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin.Semantic proximity Read ↗

Triple-helical peptides: an approach to collagen conformation, stability, and self-association.Semantic proximity Read ↗

Role of proline residues in conferring thermostability on aqualysin I.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.