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Article

Effects of disulfide bonds on folding behavior and mechanism of the beta-sheet protein tendamistat.

Biophysical journal - 1 Jan 2006

Qin Meng, Zhang Jian, Wang Wei

Abstract excerpt

Tendamistat, a small disulfide-bonded beta-sheet protein, and its three single/double-disulfide mutants are investigated by using a modified Gō-like model, aiming to understand the folding mechanism of disulfide-bonded protein as well as the effects of removal of disulfide bond on the folding process. Our simulations show that tendamistat and its two single-disulfide mutants are all two-state folders, consistent...

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Identifiers

PMID: 16214873
DOI: 10.1529/biophysj.105.063552
PMCID: PMC1367026

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