Article
Arylamine N-acetyltransferase (NAT2) genotypes in Africans: the identification of a new allele with nucleotide changes 481C>T and 590G>A.
Pharmacogenetics - 1 Jan 2003
Dandara Collet, Masimirembwa Collen M, Magimba Ayoub, Kaaya Sylvia, Sayi Jane, Sommers De K, Snyman J R, Hasler Julia A
Abstract excerpt
This study was carried out to characterize the distribution of NAT2 allelic variants among a sample of three African populations. We determined the frequencies of major NAT2 allele clusters (NAT2*4, *6, *7 and *14) using PCR/restriction fragment length polymorphism and sequencing techniques. The genotypes predict slow acetylator phenotypes of 49, 38 and 52% among Tanzanians, Venda and Zimbabweans, respectively....
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