Article
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.
Nature - 23 Jan 2003
Kemper Claudia, Chan Andrew C, Green Jonathan M, Brett Kelly A, Murphy Kenneth M, Atkinson John P
Abstract excerpt
The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. Unresponsiveness to harmless antigens is established through central and peripheral processes. Whereas clonal deletion and anergy are mechanisms of peripheral tolerance, active suppression by T-regulatory 1 (Tr1) cells has...
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