Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD46: A complement regulator and pathogen receptor that mediates links between innate and acquired immune function

24 Jun 2004

Abstract excerpt

In the last 10 years, the human cell-surface molecule, CD46, has evolved from 'just another complement regulator' to a receptor for a striking array of pathogens. CD46 not only protects cells from complement-mediated attack and facilitates infection by a large number of pathogens, but also exerts complex effects on cellular immune function. It has been proposed that CD46 links innate and adaptive immunity by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Herpesvirus Infections and Treatments
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15245366
DOI: 10.1111/j.1399-0039.2004.00277.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD46: A complement regulator and pathogen receptor that mediates links between innate and acquired immune functionPMID 15245366Read ↗

CD46 in innate and adaptive immunity: an update.Semantic proximity Read ↗

CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).Semantic proximity Read ↗

CD46: expanding beyond complement regulationSemantic proximity Read ↗

CD46 accelerates macrophage-mediated host susceptibility to meningococcal sepsis in a murine model.Semantic proximity Read ↗

Four Viruses, Two Bacteria, and One Receptor: Membrane Cofactor Protein (CD46) as Pathogens' MagnetSemantic proximity Read ↗

Human Herpesvirus 6 and Measles Virus Employ Distinct CD46 Domains for Receptor FunctionSemantic proximity Read ↗

Measles virus receptor properties are shared by several CD46 isoforms differing in extracellular regions and cytoplasmic tails.Semantic proximity Read ↗

Complement regulator CD46: genetic variants and disease associations.Semantic proximity Read ↗

CD46 in Meningococcal DiseaseSemantic proximity Read ↗

CD46 Is a Cellular Receptor for Human Herpesvirus 6Semantic proximity Read ↗

The human CD46 molecule is a receptor for measles virus (Edmonston strain)Semantic proximity Read ↗

Membrane Cofactor Protein (MCP or CD46): Newest Member of the Regulators of Complement Activation Gene ClusterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.