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Article

CD46 in innate and adaptive immunity: an update.

Clinical and experimental immunology - 1 Jun 2011

Cardone J, Le Friec G, Kemper C

Abstract excerpt

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated...

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Source

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Identifiers

PMID: 21488871
DOI: 10.1111/j.1365-2249.2011.04400.x
PMCID: PMC3087925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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