Article
Trapping of peptide-based surrogates in an artificially created channel of cytochrome c peroxidase.
Protein science : a publication of the Protein Society - 1 Feb 2003
Hays Anna-Maria A, Gray Harry B, Goodin David B
Abstract excerpt
As recently described, the deliberate removal of the proposed electron transfer pathway from cytochrome c peroxidase resulted in the formation of an extended ligand-binding channel. The engineered channel formed a template for the removed peptide segment, suggesting that synthetic surrogates might be introduced to replace the native electron transfer pathway. This approach could be united with the recent...
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