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Article

Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003

Charest Alan, Kheifets Vicky, Park Julie, Lane Keara, McMahon Kevin, Nutt Cathy L, Housman David

Abstract excerpt

Activating oncogenic mutations of receptor tyrosine kinases (RTKs) have been reported in several types of cancers. In many cases, genomic rearrangements lead to the fusion of unrelated genes to the DNA coding for the kinase domain of RTKs. All RTK-derived fusion proteins reported so far display oligomerization sequences within the 5' fusion partners that are responsible for oncogenic activation. Here, we report a...

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Share to Chromosomes, Human, Pair 6
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Golgi Apparatus

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Source

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Identifiers

PMID: 12538861
DOI: 10.1073/pnas.242741799
PMCID: PMC298701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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