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Article

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.

PloS one - 1 Jan 2014

Lee Joanna Y, Hong Wan-Jen, Majeti Ravindra, Stearns Tim

Abstract excerpt

Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling. The function of centrosome proteins in these fusions is not well understood. Among others, kinase centrosome localization and constitutive kinase dimerization are...

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Topics

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Share to Centrosome
Share to Gene Order
Share to Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloproliferative Disorders

Share to Oncogene Proteins, Fusion

Share to Phospholipase C gamma

Share to Protein Multimerization

Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 24658090
DOI: 10.1371/journal.pone.0092641
PMCID: PMC3962438

Genes

FGFR1
IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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