Article
Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2003
Grubor-Bauk Branka, Simmons Anthony, Mayrhofer Graham, Speck Peter G
Abstract excerpt
Ag-presenting molecule CD1 and CD1-restricted NKT cells are known to contribute to defense against a range of infectious pathogens, including some viruses. CD1-restricted NKT cells, a distinct subpopulation of T cells, have striking and rapid effector functions that contribute to host defense, including rapid production of IFN-gamma and IL-4, and activation of NK cells. Consideration of the important...
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