Article
Improving the detection of p53 mutations in breast cancer by use of the FASAY, a functional assay.
The Journal of molecular diagnostics : JMD - 1 Aug 2000
Duddy P M, Hanby A M, Barnes D M, Camplejohn R S
Abstract excerpt
The aim of this investigation was to examine the ability of the yeast-based functional assay, the functional analysis for the separation of alleles in yeast (FASAY), to detect p53 mutations in breast cancers when compared with immunohistochemistry and automated sequencing of the whole p53 gene (exons 1-11). To achieve this, all three methods were carried out on a cohort of aggressive breast tumors. In those...
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