Article
Virus subversion of the MHC class I peptide-loading complex.
Immunity - 1 Jan 2003
Lybarger Lonnie, Wang Xiaoli, Harris Michael R, Virgin Herbert W, Hansen Ted H
Abstract excerpt
Many viral proteins modulate class I expression, yet, in general, their mechanisms of specific class I recognition are poorly understood. The mK3 protein of gamma(2)-Herpesvirus 68 targets the degradation of nascent class I molecules via the ubiquitin/proteasome pathway. Here, we identify cellular components of the MHC class I assembly machinery, TAP and tapasin, that are required for mK3 function. mK3 failed to...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Animals
- Antigen Presentation
- Antiporters
- Calreticulin
- Cell Line
- Down-Regulation
- Gammaherpesvirinae