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Article

Virus subversion of the MHC class I peptide-loading complex.

Immunity - 1 Jan 2003

Lybarger Lonnie, Wang Xiaoli, Harris Michael R, Virgin Herbert W, Hansen Ted H

Abstract excerpt

Many viral proteins modulate class I expression, yet, in general, their mechanisms of specific class I recognition are poorly understood. The mK3 protein of gamma(2)-Herpesvirus 68 targets the degradation of nascent class I molecules via the ubiquitin/proteasome pathway. Here, we identify cellular components of the MHC class I assembly machinery, TAP and tapasin, that are required for mK3 function. mK3 failed to...

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PMID: 12530981
DOI: 10.1016/s1074-7613(02)00509-5

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