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Article

MHC class I ubiquitination by a viral PHD/LAP finger protein.

Immunity - 1 Oct 2001

Boname J M, Stevenson P G

Abstract excerpt

The murine gamma-herpesvirus-68 K3 (MK3) is a PHD/LAP finger protein that downregulates major histocompatibility complex (MHC) class I expression. In transfected cell lines, MK3 was expressed in the endoplasmic reticulum (ER) membrane, where it bound the cytoplasmic tail of newly synthesized H-2D(b) glycoproteins and targeted them for degradation. Proteasome inhibitors blocked the degradation and led to an...

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Identifiers

PMID: 11672544
DOI: 10.1016/s1074-7613(01)00213-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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