Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coupling of agonist binding to channel gating in the GABA(A) receptor.

Nature - 16 Jan 2003

Kash Thomas L, Jenkins Andrew, Kelley Jill C, Trudell James R, Harrison Neil L

Abstract excerpt

Neurotransmitters such as acetylcholine and GABA (gamma-aminobutyric acid) mediate rapid synaptic transmission by activating receptors belonging to the gene superfamily of ligand-gated ion channels (LGICs). These channels are pentameric proteins that function as signal transducers, converting chemical messages into electrical signals. Neurotransmitters activate LGICs by interacting with a ligand-binding site,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Disulfides
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Ion Channel Gating

Share to Ligands

Share to Receptors, GABA-A

Share to Static Electricity

Source

Identifiers

PMID: 12529644
DOI: 10.1038/nature01280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coupling of agonist binding to channel gating in the GABA(A) receptor.PMID 12529644Read ↗

Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.Semantic proximity Read ↗

Mutation of valine 53 at the interface between extracellular and transmembrane domains of the β2 principal subunit affects the GABAA receptor gating.Semantic proximity Read ↗

Interaction between GABAA receptor α1 and β2 subunits at the N-terminal peripheral regions is crucial for receptor binding and gating.Semantic proximity Read ↗

β2E153 Residue at Loop B of GABAAR Is Involved in Agonist Stabilization and Gating Properties.Semantic proximity Read ↗

Principal pathway coupling agonist binding to channel gating in nicotinic receptors.Semantic proximity Read ↗

Mutations of α1F45 residue of GABAA receptor loop G reveal its involvement in agonist binding and channel opening/closing transitions.Semantic proximity Read ↗

Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexes.Semantic proximity Read ↗

A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics.Semantic proximity Read ↗

Glycine substitution of α1F64 residue at the loop D of GABAA receptor impairs gating - Implications for importance of binding site-channel gate linker rigidity.Semantic proximity Read ↗

Agonist- and competitive antagonist-induced movement of loop 5 on the alpha subunit of the neuronal alpha4beta4 nicotinic acetylcholine receptor.Semantic proximity Read ↗

Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.Semantic proximity Read ↗

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmissionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.