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Article

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2003

Hinojosa-Kurtzberg A Marina, Johansson Malin E V, Madsen Cathy S, Hansson Gunnar C, Gendler Sandra J

Abstract excerpt

A cystic fibrosis (CF) mouse expressing the human mucin MUC1 transgene (CFM) reverted the CF/Muc1(-/-) phenotype (little mucus accumulated in the intestine) to that of CF mice expressing mouse Muc1, which exhibited increased mucus accumulation. Western blots and immunohistochemical analysis showed that the MUC1 protein was markedly increased in CFM mice in which it was both membrane bound and secreted into the...

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Source

Identifiers

PMID: 12529261
DOI: 10.1152/ajpgi.00326.2002

Genes

MUC1
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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