Article
Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Sept 2010
Braun Josephine, Mundhenk Lars, Range Friederike, Gruber Achim D
Abstract excerpt
BACKGROUND: Diversity of cystic fibrosis (CF) phenotype in patients with the same CFTR-mutation raised the hypothesis that other factors modulate the phenotype including "alternative" calcium-activated anion currents (CaCC). This study compares the mRNA expression levels of candidate CaCC mediators in CF mouse models with wild type controls. METHODS: mBEST1, mBEST2, mCLC-3B, mCLC-4, mTTYH3, mTMEM16A, mTMEM16F,...
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