Article
A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.
Human molecular genetics - 1 Oct 1993
O'Neal W K, Hasty P, McCray P B, Casey B, Rivera-Pérez J, Welsh M J, Beaudet A L, Bradley A
Abstract excerpt
To develop an animal model for cystic fibrosis (CF), targeted gene disruption in embryonic stem (ES) cells was used to generate a duplication of exon 3 (cftrm1Bay allele) of the mouse CF gene. ES cells containing this mutation were used to generate chimeric animals that transmitted the mutant allele through the germline. Homozygous mutant animals display a severe phenotype, with approximately 40% dying within 1...
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