Article
A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.
Human molecular genetics - 1 Oct 1993
O'Neal W K, Hasty P, McCray P B, Casey B, Rivera-Pérez J, Welsh M J, Beaudet A L, Bradley A
Abstract excerpt
To develop an animal model for cystic fibrosis (CF), targeted gene disruption in embryonic stem (ES) cells was used to generate a duplication of exon 3 (cftrm1Bay allele) of the mouse CF gene. ES cells containing this mutation were used to generate chimeric animals that transmitted the mutant all...
Topics
- Alleles
- Animals
- Base Sequence
- Chloride Channels
- Chlorides
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Exocrine Glands
- Exons
- Female
- Fertility
- Fetal Diseases
- Intestinal Obstruction
- Intestine, Small
- Lung
- Male