Article
Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis.
The Journal of biological chemistry - 10 May 2002
González-Guerrico Anatilde M, Cafferata Eduardo G, Radrizzani Martí, Marcucci Florencia, Gruenert Dieter, Pivetta Omar H, Favaloro Roberto R, Laguens Rubén, Perrone Sergio V, Gallo Guillermo C, Santa-Coloma Tomás A
Abstract excerpt
Cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) chloride channel, is associated in the respiratory system with the accumulation of mucus and impaired lung function. The role of the CFTR channel in the regulation of the intracellular pathways that determine the overexpression of mucin genes is unknown. Using differential display, we have observed the...
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