Article
Glycoconjugate metabolism in a cystic fibrosis knockout mouse model.
Molecular genetics and metabolism - 1 Feb 2001
Mailleau C, Paul A, Colin M, Xing P X, Guernier C, Bernaudin J F, Capeau J, Brahimi-Horn M C
Abstract excerpt
Cystic fibrosis knockout mice (cftr(-/-)) die prematurely of obstruction of the intestine which may result from accumulation of dehydrated glycoconjugate-containing mucus. We noted an increase in the specific activity of [(14)C]glucosamine-labeled high-molecular weight glycoconjugates, probably mucin, in the lumen of the intestine of cftr(-/-) (homozygous) mice compared to cftr(+/+) (wild-type) and cftr(+/-)...
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