Article
Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms.
Cancer immunology, immunotherapy : CII - 1 Mar 2013
Zhang Lixin, Vlad Anda, Milcarek Christine, Finn Olivera J
Abstract excerpt
MUC1 is a transmembrane mucin with important functions in normal and transformed cells, carried out by the extracellular domain or the cytoplasmic tail. A characteristic feature of the MUC1 extracellular domain is the variable number of tandem repeats (VNTR) region. Alternative splicing may regulate MUC1 expression and possibly function. We developed an RT-PCR method for efficient isolation of MUC1 mRNA isoforms...
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