Article
Inferring functional constraints and divergence in protein families using 3D mapping of phylogenetic information.
Nucleic acids research - 15 Jan 2003
Blouin Christian, Boucher Yan, Roger Andrew J
Abstract excerpt
Comparative sequence analysis has been used to study specific questions about the structure and function of proteins for many years. Here we propose a knowledge-based framework in which the maximum likelihood rate of evolution is used to quantify the level of constraint on the identity of a site. We demonstrate that site-rate mapping on 3D structures using datasets of rhodopsin-like G-protein receptors and alpha-...
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