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Article

A hierarchical approach to protein molecular evolution

16 Mar 1999

Abstract excerpt

Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo simulations. These simulations demonstrate that nonhomologous juxtaposition of encoded structure is the rate-limiting step in the production of new tertiary...

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Identifiers

PMID: 10077554
DOI: 10.1073/pnas.96.6.2591

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