Article
Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.
Gene - 2 Jan 2003
Marreiros Alexandra, Czolij Robert, Yardley Gina, Crossley Merlin, Jackson Paul
Abstract excerpt
The mechanism underlying loss of KAI1 gene expression in invasive and metastatic tumour cells is unknown. A possible scenario could involve altered expression or function of protein factors normally involved in regulating KAI1 transcription. To explore this possibility, we have initiated a study to characterise regulatory elements of the KAI1 promoter, using as a model, two bladder cancer cell lines (BL13 and...
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