Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.

doi:10.1016/s0378-1119(02)01101-0

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Article

Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.

Gene - 2 Jan 2003

Marreiros Alexandra, Czolij Robert, Yardley Gina, Crossley Merlin, Jackson Paul

Abstract excerpt

The mechanism underlying loss of KAI1 gene expression in invasive and metastatic tumour cells is unknown. A possible scenario could involve altered expression or function of protein factors normally involved in regulating KAI1 transcription. To explore this possibility, we have initiated a study to characterise regulatory elements of the KAI1 promoter, using as a model, two bladder cancer cell lines (BL13 and...

Topics

Antigens, CD
Base Sequence
Binding Sites
Chloramphenicol O-Acetyltransferase
DNA
DNA-Binding Proteins
Gene Expression
Humans
Kangai-1 Protein
Membrane Glycoproteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Protein Binding

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-jun

RNA, Messenger

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 12527206
DOI: 10.1016/s0378-1119(02)01101-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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