Article
Genotypic and phenotypic resistance: longitudinal and sequential analysis of hepatitis B virus polymerase mutations in patients with lamivudine resistance after liver transplantation.
The American journal of gastroenterology - 1 Jan 2003
Ben-Ari Ziv, Daudi Nili, Klein Athalia, Sulkes Jaqueline, Papo Orit, Mor Eytan, Samra Zmira, Gadba Rachamim, Shouval Daniel, Tur-Kaspa Ran
Abstract excerpt
OBJECTIVE: Lamivudine-resistant strains appear in 27-62.5% of liver transplant recipients treated with lamivudine for hepatitis B virus (HBV) recurrence, and may lead to failure of antiviral therapy. In an extension of our previous study, we investigated the molecular events associated with the emergence of lamivudine-resistant mutants in this population. METHODS: Sequential serum samples from 10 consecutive...
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