Article
Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation.
Antiviral therapy - 1 Jan 1999
Cane P A, Mutimer D, Ratcliffe D, Cook P, Beards G, Elias E, Pillay D
Abstract excerpt
This report describes nucleotide sequence analysis of part of the polymerase gene of hepatitis B virus (HBV) during the development of lamivudine-resistant HBV in five patients who received lamivudine treatment in conjunction with liver transplantation. Samples from patients were analysed before, during and after drug treatment in conjunction with serum HBV quantification by PCR. Lamivudine resistance was found...
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