Article
[Clinical and virologic characteristics of lamivudine resistance in HBV-associated chronic liver disease].
Taehan Kan Hakhoe chi = The Korean journal of hepatology - 1 Dec 2002
Kim Sun Suk, Chung Moon Gi, Ju Ki Tak, Park Dong Kyun, Kwon Oh Sang, Koo Yang Suh, Kim Yu Kyung, Choi Duck Ju, Hwang Yu Jin, Kim Ju Hyun
Abstract excerpt
BACKGROUND/AIMS: Lamivudine therapy in chronic hepatitis B has been shown to be effective in inhibiting HBV replication. However, lamivudine resistance has been developed with prolonged use. We studied to determine the prevalence, predictive factors, and clinical outcomes of lamivudine resistance. Mutations in YMDD motif of HBV polymerase, which have been associated with lamivudine resistance, were also assessed....
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