DNA polymorphism in B-domain of the estrogen receptor-alpha among Japanese women.

doi:10.1016/s0039-128x(97)00157-8

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Article

DNA polymorphism in B-domain of the estrogen receptor-alpha among Japanese women.

Steroids - 1 Mar 1998

Fujimoto J, Hirose R, Ichigo S, Sakaguchi H, Tamaya T

Abstract excerpt

A silent mutation in B-domain of the estrogen receptor-alpha (ER B) change codon 87 (from GCG to GCC) is clinically correlated with frequent spontaneous abortion and familial history of breast cancer among Caucasian patients. However, none of the 167 Japanese female patients and 46 Japanese femal...

Topics

Abortion, Spontaneous
Adolescent
Adult
Aged
Asian People
Blotting, Southern
Breast Neoplasms
DNA
Estrogen Receptor alpha
Female
Genetic Predisposition to Disease
Genotype
Humans
Japan
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Pregnancy

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